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Impact of PET/CT image reconstruction methods and liver uptake normalization strategies on quantitative image analysis.
Kuhnert, Georg; Boellaard, Ronald; Sterzer, Sergej; Kahraman, Deniz; Scheffler, Matthias; Wolf, Jürgen; Dietlein, Markus; Drzezga, Alexander; Kobe, Carsten.
Afiliação
  • Kuhnert G; Department of Nuclear Medicine, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
  • Boellaard R; Department of Radiology and Nuclear Medicine, VU University Medical Centre, Amsterdam, The Netherlands.
  • Sterzer S; Department of Nuclear Medicine, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
  • Kahraman D; Department of Nuclear Medicine, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
  • Scheffler M; Lung Cancer Group Cologne, Department I of Internal Medicine, Center for Integrated Oncology Cologne Bonn, University Hospital of Cologne, Cologne, Germany.
  • Wolf J; Lung Cancer Group Cologne, Department I of Internal Medicine, Center for Integrated Oncology Cologne Bonn, University Hospital of Cologne, Cologne, Germany.
  • Dietlein M; Department of Nuclear Medicine, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
  • Drzezga A; Department of Nuclear Medicine, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
  • Kobe C; Department of Nuclear Medicine, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. carsten.kobe@uk-koeln.de.
Eur J Nucl Med Mol Imaging ; 43(2): 249-258, 2016 Feb.
Article em En | MEDLINE | ID: mdl-26280981
ABSTRACT

BACKGROUND:

In oncological imaging using PET/CT, the standardized uptake value has become the most common parameter used to measure tracer accumulation. The aim of this analysis was to evaluate ultra high definition (UHD) and ordered subset expectation maximization (OSEM) PET/CT reconstructions for their potential impact on quantification. PATIENTS AND

METHODS:

We analyzed 40 PET/CT scans of lung cancer patients who had undergone PET/CT. Standardized uptake values corrected for body weight (SUV) and lean body mass (SUL) were determined in the single hottest lesion in the lung and normalized to the liver for UHD and OSEM reconstruction. Quantitative uptake values and their normalized ratios for the two reconstruction settings were compared using the Wilcoxon test. The distribution of quantitative uptake values and their ratios in relation to the reconstruction method used were demonstrated in the form of frequency distribution curves, box-plots and scatter plots. The agreement between OSEM and UHD reconstructions was assessed through Bland-Altman analysis.

RESULTS:

A significant difference was observed after OSEM and UHD reconstruction for SUV and SUL data tested (p < 0.0005 in all cases). The mean values of the ratios after OSEM and UHD reconstruction showed equally significant differences (p < 0.0005 in all cases). Bland-Altman analysis showed that the SUV and SUL and their normalized values were, on average, up to 60 % higher after UHD reconstruction as compared to OSEM reconstruction.

CONCLUSION:

OSEM and HD reconstruction brought a significant difference for SUV and SUL, which remained constantly high after normalization to the liver, indicating that standardization of reconstruction and the use of comparable SUV measurements are crucial when using PET/CT.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Processamento de Imagem Assistida por Computador / Tomografia Computadorizada por Raios X / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons / Imagem Multimodal / Fígado / Neoplasias Pulmonares Tipo de estudo: Evaluation_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Processamento de Imagem Assistida por Computador / Tomografia Computadorizada por Raios X / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons / Imagem Multimodal / Fígado / Neoplasias Pulmonares Tipo de estudo: Evaluation_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article