A new bioactive steroidal ketone from the South China Sea sponge Xestospongia testudinaria.
J Asian Nat Prod Res
; 18(2): 195-9, 2016.
Article
em En
| MEDLINE
| ID: mdl-26289715
ABSTRACT
A new steroidal ketone (1), with an ergosta-22,25-diene side chain, was obtained from the South China Sea marine sponge Xestospongia testudinaria. The structure of 1 was determined on the basis of detailed spectroscopic analysis and by comparison with literature. Compound 1 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of type II diabetes and obesity, with an IC50 value of 4.27 ± 0.55 µM, which is comparable with the positive control oleanolic acid (IC50 = 2.63 ± 0.22 µM).
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colestanóis
/
Xestospongia
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article