Hedgehog signaling indirectly affects tubular cell survival after obstructive kidney injury.

Rauhauser, Alysha A; Ren, Chongyu; Lu, Dongmei; Li, Binghua; Zhu, Jili; McEnery, Kayla; Vadnagara, Komal; Zepeda-Orozco, Diana; Zhou, Xin J; Lin, Fangming; Jetten, Anton M; Attanasio, Massimo

Rauhauser, Alysha A; Ren, Chongyu; Lu, Dongmei; Li, Binghua; Zhu, Jili; McEnery, Kayla; Vadnagara, Komal; Zepeda-Orozco, Diana; Zhou, Xin J; Lin, Fangming; Jetten, Anton M; Attanasio, Massimo.

Afiliação

Rauhauser AA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas Texas;
Ren C; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas Texas;
Lu D; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas Texas;
Li B; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas Texas;
Zhu J; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas Texas; Department of Nephrology, Wuhan University, Hubei, Wuhan, China;
McEnery K; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas Texas;
Vadnagara K; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas Texas;
Zepeda-Orozco D; Department of Pediatrics, University of Iowa, Iowa City, Iowa;
Zhou XJ; Renal Path Diagnostics, Pathologist BioMedical Laboratories and Department of Pathology, Baylor University Medical Center, Dallas, Texas;
Lin F; Department of Pediatrics, Pathology, and Cell Biology, Columbia University, New York, New York;
Jetten AM; Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina; and.
Attanasio M; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas Texas; Eugene McDermott Center for Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas massimo.attanasio@utsouthwestern.edu.

Am J Physiol Renal Physiol ; 309(9): F770-8, 2015 Nov 01.

Article em En | MEDLINE | ID: mdl-26290370

Assuntos

Injúria Renal Aguda/etiologia; Proteínas Hedgehog/metabolismo; Túbulos Renais/metabolismo; Transdução de Sinais; Obstrução Ureteral/complicações; Injúria Renal Aguda/genética; Injúria Renal Aguda/metabolismo; Injúria Renal Aguda/patologia; Injúria Renal Aguda/prevenção & controle; Animais; Antígenos/metabolismo; Apoptose; Proliferação de Células; Sobrevivência Celular; Modelos Animais de Doenças; Proteínas Hedgehog/antagonistas & inibidores; Proteínas Hedgehog/genética; Túbulos Renais/efeitos dos fármacos; Túbulos Renais/patologia; Fatores de Transcrição Kruppel-Like/genética; Fatores de Transcrição Kruppel-Like/metabolismo; Macrófagos/metabolismo; Macrófagos/patologia; Masculino; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Proteínas do Tecido Nervoso/genética; Proteínas do Tecido Nervoso/metabolismo; Pericitos/metabolismo; Pericitos/patologia; Proteoglicanas/metabolismo; Receptores Acoplados a Proteínas G/genética; Receptores Acoplados a Proteínas G/metabolismo; Transdução de Sinais/efeitos dos fármacos; Receptor Smoothened; Alcaloides de Veratrum/farmacologia; Proteína GLI1 em Dedos de Zinco; beta Catenina/metabolismo

Palavras-chave

UUO; hedgehog signaling; kidney injury

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Obstrução Ureteral / Transdução de Sinais / Proteínas Hedgehog / Injúria Renal Aguda / Túbulos Renais Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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