Effects of Variations in Ligand Density on Cell Signaling.
Small
; 11(39): 5184-99, 2015 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-26292200
ABSTRACT
Multiple simultaneous interactions between receptors and ligands dictate the extracellular and intracellular activities of cells. The concept of programmable ligand display is generally used to study the interaction between ligands, displayed on surfaces at various densities, with receptors present on cell surfaces. Various strategies are discussed here to display ligands on surfaces to study their effect on cell behavior. Only very few strategies have been reported where this display combines precise control over density with lateral spacing of ligands on surfaces. In this review, selected examples of strategies to control ligand density and spacing and their implications for biological functions of cells are discussed.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Membrana Celular
/
Receptores de Superfície Celular
/
Ligantes
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article