Supratentorial white matter blurring associated with voltage-gated potassium channel-complex limbic encephalitis.
Neuroradiology
; 57(12): 1203-9, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26293130
ABSTRACT
INTRODUCTION:
Limbic encephalitis (LE) associated with voltage-gated potassium channel-complex antibodies (VGKC-LE) is frequently non-paraneoplastic and associated with marked improvement following corticosteroid therapy. Mesial temporal lobe abnormalities are present in around 80 % of patients. If associated or preceded by faciobrachial dystonic seizures, basal ganglia signal changes may occur. In some patients, blurring of the supratentorial white matter on T2-weighted images (SWMB) may be seen. The purpose of this study was to evaluate the incidence of SWMB and whether it is specific for VGKC-LE.METHODS:
Two experienced neuroradiologists independently evaluated signal abnormalities on FLAIR MRI in 79 patients with LE while unaware on the antibody type.RESULTS:
SWMB was independently assessed as present in 10 of 36 (28 %) compared to 2 (5 %) of 43 non-VGKC patients (p = 0.009). It was not related to the presence of LGI1 or CASPR2 proteins of VGKC antibodies. MRI showed increased temporomesial FLAIR signal in 22 (61 %) VGKC compared to 14 (33 %) non-VGKC patients (p = 0.013), and extratemporomesial structures were affected in one VGKC (3 %) compared to 11 (26 %) non-VGKC patients (p = 0.005).CONCLUSION:
SWMB is a newly described MRI sign rather specific for VGKC-LE.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Encefalite Límbica
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Canais de Potássio de Abertura Dependente da Tensão da Membrana
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Cérebro
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Imagem de Tensor de Difusão
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Substância Branca
Tipo de estudo:
Diagnostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article