Nano-assembly of nanodiamonds by conjugation to actin filaments.
J Biophotonics
; 9(3): 296-304, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26296437
ABSTRACT
Fluorescent nanodiamonds (NDs) are remarkable objects. They possess unique mechanical and optical properties combined with high surface areas and controllable surface reactivity. They are non-toxic and hence suited for use in biological environments. NDs are also readily available and commercially inexpensive. Here, the exceptional capability of controlling and tailoring their surface chemistry is demonstrated. Small, bright diamond nanocrystals (size Ë30 nm) are conjugated to protein filaments of actin (length Ë3-7 µm). The conjugation to actin filaments is extremely selective and highly target-specific. These unique features, together with the relative simplicity of the conjugation-targeting method, make functionalised nanodiamonds a powerful and versatile platform in biomedicine and quantum nanotechnologies. Applications ranging from using NDs as superior biological markers to, potentially, developing novel bottom-up approaches for the fabrication of hybrid quantum devices that would bridge across the bio/solid-state interface are presented and discussed.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citoesqueleto de Actina
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Nanotecnologia
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Nanodiamantes
/
Corantes Fluorescentes
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article