HiXCorr: a portable high-speed XCorr engine for high-resolution tandem mass spectrometry.
Bioinformatics
; 31(24): 4026-8, 2015 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-26315908
ABSTRACT
UNLABELLED Peptide identification is an important problem in proteomics. One of the most popular scoring schemes for peptide identification is XCorr (cross-correlation). Since calculating XCorr is computationally intensive, a lot of efforts have been made to develop fast XCorr engines. However, the existing XCorr engines are not suitable for high-resolution MS/MS spectrometry because they are either slow or require a specific type of CPU. We present a portable high-speed XCorr engine for high-resolution tandem mass spectrometry by developing a novel algorithm for calculating XCorr. The algorithm enables XCorr calculation 1.25-49 times faster than previous algorithms for 0.01 Da fragment tolerance. Furthermore, our engine is easily portable to any machine with different types of CPU because it is developed in C language. Hence, our XCorr engine will expedite peptide identification by high-resolution tandem mass spectrometry. AVAILABILITY AND IMPLEMENTATION Available at http//isa.hanyang.ac.kr/HiXCorr/HiXCorr.html.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Software
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Espectrometria de Massas em Tandem
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article