Pharmacokinetics of tecomin in rats after intragastric and intravenous administration.
Biomed Chromatogr
; 30(4): 612-7, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26317973
ABSTRACT
The pharmacokinetics of tecomin, which is a potential bioactive compound from the flowers of Trollius chinensis, was studied. The results showed that this compound was easily absorbed and rapidly metabolized into veratric acid in vivo, and then the latter was eliminated slowly. In addition, the simulant in vitro gastrointestinal transformation experiments demonstrated that the basic enteral environment and intestinal bacterial flora also contributed to the metabolism of tecomin to veratric acid.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Vanílico
/
Alcaloides
/
Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article