New Organocatalytic Asymmetric Synthesis of Highly Substituted Chiral 2-Oxospiro-[indole-3,4'- (1',4'-dihydropyridine)] Derivatives.
Molecules
; 20(9): 15807-26, 2015 Aug 31.
Article
em En
| MEDLINE
| ID: mdl-26334263
ABSTRACT
Herein, we report our preliminary results concerning the first promising asymmetric synthesis of highly functionalized 2-oxospiro-[indole-3,4'-(1',4'-dihydropyridine)] via the reaction of an enamine with isatylidene malononitrile derivatives in the presence of a chiral base organocatalyst. The moderate, but promising, enantioselectivity observed (30%-58% ee (enantiomeric excess)) opens the door to a new area of research for the asymmetric construction of these appealing spirooxindole skeletons, whose enantioselective syntheses are still very limited.
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MEDLINE
Assunto principal:
Di-Hidropiridinas
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Indóis
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article