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Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.
Peng, Sheng-Bin; Henry, James R; Kaufman, Michael D; Lu, Wei-Ping; Smith, Bryan D; Vogeti, Subha; Rutkoski, Thomas J; Wise, Scott; Chun, Lawrence; Zhang, Youyan; Van Horn, Robert D; Yin, Tinggui; Zhang, Xiaoyi; Yadav, Vipin; Chen, Shih-Hsun; Gong, Xueqian; Ma, Xiwen; Webster, Yue; Buchanan, Sean; Mochalkin, Igor; Huber, Lysiane; Kays, Lisa; Donoho, Gregory P; Walgren, Jennie; McCann, Denis; Patel, Phenil; Conti, Ilaria; Plowman, Gregory D; Starling, James J; Flynn, Daniel L.
Afiliação
  • Peng SB; Eli Lilly and Company, Indianapolis, IN 46285, USA. Electronic address: peng_sheng-bin@lilly.com.
  • Henry JR; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Kaufman MD; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA.
  • Lu WP; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA.
  • Smith BD; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA.
  • Vogeti S; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA.
  • Rutkoski TJ; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA.
  • Wise S; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA.
  • Chun L; Emerald Biostructures, Bainbridge Island, WA 98110, USA.
  • Zhang Y; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Van Horn RD; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Yin T; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Zhang X; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Yadav V; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Chen SH; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Gong X; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Ma X; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Webster Y; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Buchanan S; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Mochalkin I; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Huber L; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Kays L; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Donoho GP; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Walgren J; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • McCann D; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Patel P; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Conti I; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Plowman GD; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Starling JJ; Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Flynn DL; Deciphera Pharmaceuticals, LLC, Lawrence, KS 66044, USA.
Cancer Cell ; 28(3): 384-98, 2015 Sep 14.
Article em En | MEDLINE | ID: mdl-26343583
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Pirimidinas / Proteínas ras / Isoformas de Proteínas / Proteínas Proto-Oncogênicas B-raf / Neoplasias / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Pirimidinas / Proteínas ras / Isoformas de Proteínas / Proteínas Proto-Oncogênicas B-raf / Neoplasias / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article