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Mismatch repair in Gram-positive bacteria.
Lenhart, Justin S; Pillon, Monica C; Guarné, Alba; Biteen, Julie S; Simmons, Lyle A.
Afiliação
  • Lenhart JS; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, United States; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, United States.
  • Pillon MC; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
  • Guarné A; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada. Electronic address: guarnea@mcmaster.ca.
  • Biteen JS; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: jsbiteen@umich.edu.
  • Simmons LA; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: lasimm@umich.edu.
Res Microbiol ; 167(1): 4-12, 2016 Jan.
Article em En | MEDLINE | ID: mdl-26343983
DNA mismatch repair (MMR) is responsible for correcting errors formed during DNA replication. DNA polymerase errors include base mismatches and extra helical nucleotides referred to as insertion and deletion loops. In bacteria, MMR increases the fidelity of the chromosomal DNA replication pathway approximately 100-fold. MMR defects in bacteria reduce replication fidelity and have the potential to affect fitness. In mammals, MMR defects are characterized by an increase in mutation rate and by microsatellite instability. In this review, we discuss current advances in understanding how MMR functions in bacteria lacking the MutH and Dam methylase-dependent MMR pathway.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Bacteriano / Reparo de Erro de Pareamento de DNA / Bactérias Gram-Positivas Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Bacteriano / Reparo de Erro de Pareamento de DNA / Bactérias Gram-Positivas Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article