Altered age-related changes in bioenergetic properties and mitochondrial morphology in fibroblasts from sporadic amyotrophic lateral sclerosis patients.

Allen, Scott P; Duffy, Lynn M; Shaw, Pamela J; Grierson, Andrew J

Allen, Scott P; Duffy, Lynn M; Shaw, Pamela J; Grierson, Andrew J.

Afiliação

Allen SP; Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
Duffy LM; Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
Shaw PJ; Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
Grierson AJ; Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Electronic address: a.j.grierson@sheffield.ac.uk.

Neurobiol Aging ; 36(10): 2893-903, 2015 Oct.

Article em En | MEDLINE | ID: mdl-26344876

Assuntos

Envelhecimento/metabolismo; Envelhecimento/patologia; Esclerose Lateral Amiotrófica/metabolismo; Esclerose Lateral Amiotrófica/patologia; Fibroblastos/ultraestrutura; Mitocôndrias/metabolismo; Mitocôndrias/patologia; Adulto; Idoso; Células Cultivadas; Metabolismo Energético; Feminino; Fibroblastos/metabolismo; Glicólise; Humanos; Masculino; Pessoa de Meia-Idade; Mitocôndrias/fisiologia; Consumo de Oxigênio

Palavras-chave

ALS; Aging; Metabolism; Mitochondria; Sporadic

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Fibroblastos / Esclerose Lateral Amiotrófica / Mitocôndrias Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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