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Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis.
Chen, Zhao-Fei; Ai, Luo-Yan; Wang, Ji-Lin; Ren, Lin-Lin; Yu, Ya-Nan; Xu, Jie; Chen, Hao-Yan; Yu, Jun; Li, Min; Qin, Wen-Xin; Ma, Xiong; Shen, Nan; Chen, Ying-Xuan; Hong, Jie; Fang, Jing-Yuan.
Afiliação
  • Chen ZF; Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
  • Ai LY; Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
  • Wang JL; Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
  • Ren LL; Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
  • Yu YN; Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
  • Xu J; Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
  • Chen HY; Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
  • Yu J; Department of Medicine & Therapeutics, Institute of Digestive Disease & LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.
  • Li M; Department of Clinical Laboratory, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China.
  • Qin WX; State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University Shanghai, China.
  • Ma X; Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
  • Shen N; Division of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China.
  • Chen YX; Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
  • Hong J; Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
  • Fang JY; Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
Future Microbiol ; 10(9): 1433-45, 2015.
Article em En | MEDLINE | ID: mdl-26346930
AIMS: To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression. MATERIALS & METHODS: The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were intervened by these two probiotics and the antitumor effects were examined by comparing the tumor incidence and detecting the inflammatory and immune-related markers. RESULTS & CONCLUSIONS: C. butyricum and B. subtilis inhibited the proliferation of CRC cells, caused cell cycle arrest and promoted apoptosis. In vivo, these two probiotics inhibited the development of DMH-induced CRC. The molecular mechanism involved reduced inflammation and improved immune homeostasis. This work establishes a basis for the protective role of probiotics B. subtilis and C. butyricum in intestinal tumorigenesis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bacillus subtilis / Neoplasias Colorretais / Probióticos / Clostridium butyricum / Carcinogênese Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bacillus subtilis / Neoplasias Colorretais / Probióticos / Clostridium butyricum / Carcinogênese Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article