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Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-ß7 during Acute Graft-versus-Host Disease of the Liver.
Schreder, Alina; Moschovakis, Georgios Leandros; Halle, Stephan; Schlue, Jerome; Lee, Chun-Wei; Schippers, Angela; David, Sascha; Bernhardt, Günter; Ganser, Arnold; Pabst, Oliver; Förster, Reinhold; Koenecke, Christian.
Afiliação
  • Schreder A; Institute of Immunology, Hannover Medical School, Hannover, Germany.
  • Moschovakis GL; Institute of Immunology, Hannover Medical School, Hannover, Germany.
  • Halle S; Institute of Immunology, Hannover Medical School, Hannover, Germany.
  • Schlue J; Institute of Pathology, Hannover Medical School, Hannover, Germany.
  • Lee CW; Institute of Immunology, Hannover Medical School, Hannover, Germany.
  • Schippers A; Department of Pediatrics, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • David S; Department of Nephrology, Hannover Medical School, Hannover, Germany.
  • Bernhardt G; Institute of Immunology, Hannover Medical School, Hannover, Germany.
  • Ganser A; Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover Medical School, Hannover, Germany.
  • Pabst O; Institute of Molecular Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Förster R; Institute of Immunology, Hannover Medical School, Hannover, Germany.
  • Koenecke C; Institute of Immunology, Hannover Medical School, Hannover, Germany; Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover Medical School, Hannover, Germany. Electronic address: koenecke.christian@mh-hannover.de.
Biol Blood Marrow Transplant ; 21(12): 2069-2078, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26348893
Homing of allogeneic donor T cells to recipient tissue is imperative for the development of acute graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In this study we show that alteration of T cell homing due to integrin-ß7 deficiency on T cells or its ligand MAdCAM-1 in BMT recipients contributes to the pathophysiology of experimental GVHD. In contrast, lack of CC chemokine receptor 9 on donor T cells alters tissue homing but does not impact GVHD survival. We further demonstrate that MAdCAM-1 is aberrantly expressed in hepatic murine GVHD as well as in patients with active liver GVHD. However, infiltration of donor T cells in gut but not liver was dependent of MAdCAM-1 expression, indicating, that homing and/or retention of donor T cells rests on divergent molecular pathways depending on the GVHD target tissue.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Medula Óssea / Transplante de Fígado / Cadeias beta de Integrinas / Receptores CCR / Sobrevivência de Enxerto / Doença Enxerto-Hospedeiro Limite: Adult / Animals / Child / Humans / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Medula Óssea / Transplante de Fígado / Cadeias beta de Integrinas / Receptores CCR / Sobrevivência de Enxerto / Doença Enxerto-Hospedeiro Limite: Adult / Animals / Child / Humans / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article