Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-ß7 during Acute Graft-versus-Host Disease of the Liver.
Biol Blood Marrow Transplant
; 21(12): 2069-2078, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26348893
Homing of allogeneic donor T cells to recipient tissue is imperative for the development of acute graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In this study we show that alteration of T cell homing due to integrin-ß7 deficiency on T cells or its ligand MAdCAM-1 in BMT recipients contributes to the pathophysiology of experimental GVHD. In contrast, lack of CC chemokine receptor 9 on donor T cells alters tissue homing but does not impact GVHD survival. We further demonstrate that MAdCAM-1 is aberrantly expressed in hepatic murine GVHD as well as in patients with active liver GVHD. However, infiltration of donor T cells in gut but not liver was dependent of MAdCAM-1 expression, indicating, that homing and/or retention of donor T cells rests on divergent molecular pathways depending on the GVHD target tissue.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante de Medula Óssea
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Transplante de Fígado
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Cadeias beta de Integrinas
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Receptores CCR
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Sobrevivência de Enxerto
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Doença Enxerto-Hospedeiro
Limite:
Adult
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Animals
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Child
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article