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Quercetin reduces Ehrlich tumor-induced cancer pain in mice.
Calixto-Campos, Cassia; Corrêa, Mab P; Carvalho, Thacyana T; Zarpelon, Ana C; Hohmann, Miriam S N; Rossaneis, Ana C; Coelho-Silva, Leticia; Pavanelli, Wander R; Pinge-Filho, Phileno; Crespigio, Jefferson; Bernardy, Catia C F; Casagrande, Rubia; Verri, Waldiceu A.
Afiliação
  • Calixto-Campos C; Department of Pathology, Biological Sciences Centre, Londrina State University, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, PR, Brazil.
  • Corrêa MP; Department of Pathology, Biological Sciences Centre, Londrina State University, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, PR, Brazil.
  • Carvalho TT; Department of Pathology, Biological Sciences Centre, Londrina State University, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, PR, Brazil.
  • Zarpelon AC; Department of Pathology, Biological Sciences Centre, Londrina State University, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, PR, Brazil.
  • Hohmann MS; Department of Pathology, Biological Sciences Centre, Londrina State University, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, PR, Brazil.
  • Rossaneis AC; Department of Pathology, Biological Sciences Centre, Londrina State University, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, PR, Brazil.
  • Coelho-Silva L; Department of Pathology, Biological Sciences Centre, Londrina State University, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, PR, Brazil.
  • Pavanelli WR; Department of Pathology, Biological Sciences Centre, Londrina State University, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, PR, Brazil.
  • Pinge-Filho P; Department of Pathology, Biological Sciences Centre, Londrina State University, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, PR, Brazil.
  • Crespigio J; Department of Pathology, Biological Sciences Centre, Londrina State University, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, PR, Brazil.
  • Bernardy CC; Department of Nursing, Health Science Centre, Londrina State University, Avenue Robert Koch 60, 86038-350 Londrina, PR, Brazil.
  • Casagrande R; Department of Pharmaceutical Sciences, Health Science Centre, Londrina State University, Avenue Robert Koch 60, 86038-350 Londrina, PR, Brazil.
  • Verri WA; Department of Pathology, Biological Sciences Centre, Londrina State University, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, PR, Brazil.
Anal Cell Pathol (Amst) ; 2015: 285708, 2015.
Article em En | MEDLINE | ID: mdl-26351625
Cancer pain directly affects the patient's quality of life. We have previously demonstrated that the subcutaneous administration of the mammary adenocarcinoma known as Ehrlich tumor induces pain in mice. Several studies have shown that the flavonoid quercetin presents important biological effects, including anti-inflammatory, antioxidant, analgesic, and antitumor activity. Therefore, the analgesic effect and mechanisms of quercetin were evaluated in Ehrlich tumor-induced cancer pain in mice. Intraperitoneal (i.p.) treatments with quercetin reduced Ehrlich tumor-induced mechanical and thermal hyperalgesia, but not paw thickness or histological alterations, indicating an analgesic effect without affecting tumor growth. Regarding the analgesic mechanisms of quercetin, it inhibited the production of hyperalgesic cytokines IL-1ß and TNFα and decreased neutrophil recruitment (myeloperoxidase activity) and oxidative stress. Naloxone (opioid receptor antagonist) inhibited quercetin analgesia without interfering with neutrophil recruitment, cytokine production, and oxidative stress. Importantly, cotreatment with morphine and quercetin at doses that were ineffective as single treatment reduced the nociceptive responses. Concluding, quercetin reduces the Ehrlich tumor-induced cancer pain by reducing the production of hyperalgesic cytokines, neutrophil recruitment, and oxidative stress as well as by activating an opioid-dependent analgesic pathway and potentiation of morphine analgesia. Thus, quercetin treatment seems a suitable therapeutic approach for cancer pain that merits further investigation.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Quercetina / Carcinoma de Ehrlich Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Quercetina / Carcinoma de Ehrlich Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article