Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing.
Biomaterials
; 72: 104-11, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26352517
ABSTRACT
Urinary fistulas, abnormal openings of a urinary tract organ, are serious complications and conventional management strategies are not satisfactory. For more effective and non-invasive fistula repair, fluid tissue adhesives or sealants have been suggested. However, conventional products do not provide a suitable solution due to safety problems and poor underwater adhesion under physiological conditions. Herein, we proposed a unique water-immiscible mussel protein-based bioadhesive (WIMBA) exhibiting strong underwater adhesion which was employed by two adhesion strategies of marine organisms; 3,4-dihydroxy-l-phenylalanine (DOPA)-mediated strong adhesion and water-immiscible coacervation. The developed biocompatible WIMBA successfully sealed ex vivo urinary fistulas and provided good durability and high compliance. Thus, WIMBA could be used as a promising sealant for urinary fistula management with further expansion to diverse internal body applications.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Água
/
Proteínas
/
Fístula Urinária
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article