Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation.
J Immunol
; 195(8): 3531-6, 2015 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-26355150
ABSTRACT
Memory/effector T cells recirculate through extralymphoid tissues by entering from blood and egressing via afferent lymph. Although T cell entry into effector sites is key to inflammation, the relevance of T cell egress to this process is unknown. In this study, we found that Ag recognition at the effector site reduced the tissue egress of proinflammatory Th1 cells in a mouse model of delayed hypersensitivity. Transgenic expression of "tissue exit receptor" CCR7 enhanced lymphatic egress of Ag-sequestered Th1 cells from the inflamed site and alleviated inflammation. In contrast, lack of CCR7 on Th1 cells diminished their tissue egress while enhancing inflammation. Lymph-borne Th1 and Th17 cells draining the inflamed skin of sheep migrated toward the CCR7 ligand CCL21, suggesting the CCR7-CCL21 axis as a physiological target in regulating inflammation. In conclusion, exit receptors can be targeted to modulate T cell dwell time and inflammation at effector sites, revealing T cell tissue egress as a novel control point of inflammation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Movimento Celular
/
Células Th1
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Células Th17
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Hipersensibilidade Tardia
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article