Biochemical Characterization of VIM-39, a VIM-1-Like Metallo-ß-Lactamase Variant from a Multidrug-Resistant Klebsiella pneumoniae Isolate from Greece.
Antimicrob Agents Chemother
; 59(12): 7811-4, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26369975
ABSTRACT
VIM-39, a VIM-1-like metallo-ß-lactamase variant (VIM-1 Thr33Ala His224Leu) was identified in a clinical isolate of Klebsiella pneumoniae belonging to sequence type 147. VIM-39 hydrolyzed ampicillin, cephalothin, and imipenem more efficiently than did VIM-1 and VIM-26 (a VIM-1 variant with the His224Leu substitution) because of higher turnover rates.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cefalotina
/
Imipenem
/
Ampicilina
/
Klebsiella pneumoniae
/
Antibacterianos
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article