Diamine Functionalized Cubic Mesoporous Silica for Ibuprofen Controlled Delivery.
J Nanosci Nanotechnol
; 15(7): 4784-91, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26373038
ABSTRACT
A diamine functionalized cubic mesostructured KIT-6 (N-KIT-6) has been prepared by post-synthetic method using calcined mesoporous KIT-6 with a diamine source, i.e., N-'[3-(tri methoxysilyl)- propyl]'ethylenediamine. The KIT-6 mesoporous silica used for N-KIT-6 was synthesized under weak acidic hydrothermal method using bitemplates, viz., Pluronic P123 and 1-butanol. The synthesized mesoporous materials, KIT-6 and N-KIT-6, have been characterized by the relevant instrumental techniques such as SAXS, N2 sorption isotherm, FT-IR, SEM, TEM and TGA to prove the standard mesoporous materials with the identification of diamine groups. The characterized mesoporous materials, KIT-6 and N-KIT-6, have been extensively used in the potential application of controlled drug delivery, where ibuprofen (IBU) employed as a model drug. The rate of IBU adsorption and release was monitored by UV vis-spectrometer. On the basis of the experimental results of controlled drug delivery system, the results of IBU adsorption and releasing rate in N-KIT-6 are higher than those of KIT-6 because of the higher hydrophobic nature as well as rich basic sites on the surface of inner pore wall silica.
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Base de dados:
MEDLINE
Assunto principal:
Ibuprofeno
/
Dióxido de Silício
/
Analgésicos não Narcóticos
/
Diaminas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article