Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells.

Nigam, Nupur; Grover, Abhinav; Goyal, Sukriti; Katiyar, Shashank P; Bhargava, Priyanshu; Wang, Pi-Chao; Sundar, Durai; Kaul, Sunil C; Wadhwa, Renu

Nigam, Nupur; Grover, Abhinav; Goyal, Sukriti; Katiyar, Shashank P; Bhargava, Priyanshu; Wang, Pi-Chao; Sundar, Durai; Kaul, Sunil C; Wadhwa, Renu.

Afiliação

Nigam N; Drug Discovery and Assets Innovation Lab, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Biomedical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan; Graduate School of Life and Environmental Sciences, University of T
Grover A; School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.
Goyal S; School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.
Katiyar SP; Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology (IIT) Delhi, New Delhi, India.
Bhargava P; Drug Discovery and Assets Innovation Lab, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Biomedical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan; Graduate School of Life and Environmental Sciences, University of T
Wang PC; Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.
Sundar D; Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology (IIT) Delhi, New Delhi, India.
Kaul SC; Drug Discovery and Assets Innovation Lab, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Biomedical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan.
Wadhwa R; Drug Discovery and Assets Innovation Lab, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Biomedical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan.

PLoS One ; 10(9): e0138192, 2015.

Article em En | MEDLINE | ID: mdl-26376435

Assuntos

Benzoquinonas/farmacologia; Neoplasias da Mama/tratamento farmacológico; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Proteínas de Choque Térmico HSP70/metabolismo; Primulaceae/química; Transdução de Sinais/efeitos dos fármacos; Proteína Supressora de Tumor p53/metabolismo; Apoptose; Western Blotting; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Proliferação de Células; Feminino; Proteínas de Choque Térmico HSP70/genética; Humanos; Metástase Neoplásica; Análise Serial de Proteínas; RNA Mensageiro/genética; Reação em Cadeia da Polimerase em Tempo Real; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Células Tumorais Cultivadas; Proteína Supressora de Tumor p53/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Transdução de Sinais / Regulação Neoplásica da Expressão Gênica / Benzoquinonas / Proteína Supressora de Tumor p53 / Proteínas de Choque Térmico HSP70 / Primulaceae Tipo de estudo: Etiology_studies Limite: Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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