RNA and protein expression of herpesvirus entry mediator (HVEM) is associated with molecular markers, immunity-related pathways and relapse-free survival of patients with AML.

Lichtenegger, Felix S; Kondla, Isabell; Krempasky, Michael; Weber, Anna L; Herold, Tobias; Krupka, Christina; Spiekermann, Karsten; Schneider, Stephanie; Büchner, Thomas; Berdel, Wolfgang E; Wörmann, Bernhard J; Hiddemann, Wolfgang; Subklewe, Marion

Lichtenegger, Felix S; Kondla, Isabell; Krempasky, Michael; Weber, Anna L; Herold, Tobias; Krupka, Christina; Spiekermann, Karsten; Schneider, Stephanie; Büchner, Thomas; Berdel, Wolfgang E; Wörmann, Bernhard J; Hiddemann, Wolfgang; Subklewe, Marion.

Afiliação

Lichtenegger FS; Department of Internal Medicine III, Klinikum der Universität München, Marchioninistraße 15, 81377, Munich, Germany. Felix.Lichtenegger@med.uni-muenchen.de.
Kondla I; Clinical Cooperation Group Immunotherapy, Helmholtz Zentrum München, Munich, Germany. Felix.Lichtenegger@med.uni-muenchen.de.
Krempasky M; Division of Clinical Pharmacology, Department of Internal Medicine IV, Klinikum der Universität München, Munich, Germany. Felix.Lichtenegger@med.uni-muenchen.de.
Weber AL; Department of Internal Medicine III, Klinikum der Universität München, Marchioninistraße 15, 81377, Munich, Germany.
Herold T; Clinical Cooperation Group Immunotherapy, Helmholtz Zentrum München, Munich, Germany.
Krupka C; Department of Internal Medicine III, Klinikum der Universität München, Marchioninistraße 15, 81377, Munich, Germany.
Spiekermann K; Clinical Cooperation Group Immunotherapy, Helmholtz Zentrum München, Munich, Germany.
Schneider S; Department of Internal Medicine III, Klinikum der Universität München, Marchioninistraße 15, 81377, Munich, Germany.
Büchner T; Clinical Cooperation Group Immunotherapy, Helmholtz Zentrum München, Munich, Germany.
Berdel WE; Department of Internal Medicine III, Klinikum der Universität München, Marchioninistraße 15, 81377, Munich, Germany.
Wörmann BJ; Clinical Cooperation Group Pathogenesis of Acute Leukemia, Helmholtz Zentrum München, Munich, Germany.
Hiddemann W; Department of Internal Medicine III, Klinikum der Universität München, Marchioninistraße 15, 81377, Munich, Germany.
Subklewe M; Clinical Cooperation Group Immunotherapy, Helmholtz Zentrum München, Munich, Germany.

Cancer Immunol Immunother ; 64(12): 1505-15, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26377688

Assuntos

Biomarcadores Tumorais/genética; Regulação Neoplásica da Expressão Gênica; Leucemia Mieloide Aguda/genética; Membro 14 de Receptores do Fator de Necrose Tumoral/genética; Adulto; Idoso; Idoso de 80 Anos ou mais; Medula Óssea/metabolismo; Intervalo Livre de Doença; Feminino; Citometria de Fluxo; Humanos; Leucemia Mieloide Aguda/diagnóstico; Leucemia Mieloide Aguda/imunologia; Leucemia Mieloide Aguda/mortalidade; Masculino; Pessoa de Meia-Idade; Nucleofosmina; RNA/genética; Membro 14 de Receptores do Fator de Necrose Tumoral/imunologia

Palavras-chave

Acute myeloid leukemia (AML); Costimulation; Gene expression analysis; Herpesvirus entry mediator (HVEM); Immune checkpoint molecules; Immunophenotyping

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Membro 14 de Receptores do Fator de Necrose Tumoral Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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