Effects of Oral Administration of Chitin Nanofiber on Plasma Metabolites and Gut Microorganisms.
Int J Mol Sci
; 16(9): 21931-49, 2015 Sep 10.
Article
em En
| MEDLINE
| ID: mdl-26378523
ABSTRACT
The aim of this study was to examine the effects of oral administration of chitin nanofibers (CNFs) and surface-deacetylated (SDA) CNFs on plasma metabolites using metabolome analysis. Furthermore, we determined the changes in gut microbiota and fecal organic acid concentrations following oral administrations of CNFs and SDACNFs. Healthy female mice (six-week-old) were fed a normal diet and administered tap water with 0.1% (v/v) CNFs or SDACNFs for 28 days. Oral administration of CNFs increased plasma levels of adenosine triphosphate (ATP), adenosine diphosphate (ADP), and serotonin (5-hydroxytryptamine, 5-HT). Oral administration of SDACNFs affected the metabolisms of acyl-carnitines and fatty acids. The fecal organic level analysis indicated that oral administration of CNFs stimulated and activated the functions of microbiota. These results indicate that oral administration of CNFs increases plasma levels of ATP and 5-HT via activation of gut microbiota.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quitina
/
Metaboloma
/
Nanofibras
/
Microbioma Gastrointestinal
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article