A Human Immunodeficiency Virus Controller With a Large Population of CD4(+)CD8(+) Double-Positive T Cells.

Durand, Christine M; Buckheit, Robert W; Salgado, Maria; Pohlmeyer, Christopher W; Walker-Sperling, Victoria E; Hegarty, Robert W; Ambinder, Richard F; Blankson, Joel N.

Afiliação

Durand CM; Departments of Medicine ; Oncology , Johns Hopkins School of Medicine , Baltimore, Maryland.
Buckheit RW; Departments of Medicine.
Salgado M; Departments of Medicine.
Pohlmeyer CW; Departments of Medicine.
Walker-Sperling VE; Departments of Medicine.
Hegarty RW; Departments of Medicine.
Ambinder RF; Departments of Medicine ; Oncology , Johns Hopkins School of Medicine , Baltimore, Maryland.
Blankson JN; Departments of Medicine.

Open Forum Infect Dis ; 2(2): ofv039, 2015 Apr.

Article em En | MEDLINE | ID: mdl-26380339

ABSTRACT

Human immunodeficiency virus (HIV) controllers are patients who control viral replication without antiretroviral therapy. We present the case of an HIV controller who had CD4 and CD8 coexpressed on 40% of his T cells. Although a recent study found that double-positive T cells had superior antiviral capacity in HIV-1 controllers, in this case, the CD4(+)CD8(+) T cells did not have strong antiviral activity.

Palavras-chave

AIDS; HIV; HIV controllers; double-positive cells; elite controllers; immune activation; long-term nonprogressors; viremic controllers

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article