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Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP).
Lovering, Frank; Aevazelis, Cristina; Chang, Jeanne; Dehnhardt, Christoph; Fitz, Lori; Han, Seungil; Janz, Kristin; Lee, Julie; Kaila, Neelu; McDonald, Joseph; Moore, William; Moretto, Alessandro; Papaioannou, Nikolaos; Richard, David; Ryan, Mark S; Wan, Zhao-Kui; Thorarensen, Atli.
Afiliação
  • Lovering F; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA. frank.lovering@pfizer.com.
  • Aevazelis C; Inflammation and Immunity, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Chang J; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, Eastern Point Road, Groton, CT, 06340, USA.
  • Dehnhardt C; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Fitz L; Inflammation and Immunity, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Han S; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, Eastern Point Road, Groton, CT, 06340, USA.
  • Janz K; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Lee J; Inflammation and Immunity, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Kaila N; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • McDonald J; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Moore W; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Moretto A; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Papaioannou N; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Richard D; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Ryan MS; Inflammation and Immunity, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Wan ZK; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Thorarensen A; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
ChemMedChem ; 11(2): 217-33, 2016 Jan 19.
Article em En | MEDLINE | ID: mdl-26381330
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Termodinâmica / Triazinas / Proteínas Tirosina Quinases / Peptídeos e Proteínas de Sinalização Intracelular / Inibidores de Proteínas Quinases / Imidazóis Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Termodinâmica / Triazinas / Proteínas Tirosina Quinases / Peptídeos e Proteínas de Sinalização Intracelular / Inibidores de Proteínas Quinases / Imidazóis Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article