Effect of common polymorphisms of the farnesoid X receptor and bile acid transporters on the pharmacokinetics of ursodeoxycholic acid.

Hu, Miao; Fok, Benny S P; Wo, Siu-Kwan; Lee, Vincent H L; Zuo, Zhong; Tomlinson, Brian

Hu, Miao; Fok, Benny S P; Wo, Siu-Kwan; Lee, Vincent H L; Zuo, Zhong; Tomlinson, Brian.

Afiliação

Hu M; Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Fok BS; Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Wo SK; School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong.
Lee VH; School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong.
Zuo Z; School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong.
Tomlinson B; Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.

Clin Exp Pharmacol Physiol ; 43(1): 34-40, 2016 Jan.

Article em En | MEDLINE | ID: mdl-26382575

Assuntos

Ácidos e Sais Biliares/metabolismo; Proteínas de Membrana Transportadoras/genética; Proteínas de Membrana Transportadoras/metabolismo; Polimorfismo de Nucleotídeo Único; Receptores Citoplasmáticos e Nucleares/genética; Ácido Ursodesoxicólico/farmacocinética; Adulto; Voluntários Saudáveis; Humanos; Masculino; Pessoa de Meia-Idade; Adulto Jovem

Palavras-chave

farnesoid X receptor; pharmacogenetics; pharmacokinetics; ursodeoxycholic acid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Ácido Ursodesoxicólico / Ácidos e Sais Biliares / Receptores Citoplasmáticos e Nucleares / Polimorfismo de Nucleotídeo Único Limite: Adult / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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