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Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons.
Rocha, Emily M; Smith, Gaynor A; Park, Eric; Cao, Hongmei; Brown, Eilish; Hayes, Melissa A; Beagan, Jonathan; McLean, Jesse R; Izen, Sarah C; Perez-Torres, Eduardo; Hallett, Penelope J; Isacson, Ole.
Afiliação
  • Rocha EM; Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA.
  • Smith GA; Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA.
  • Park E; Shire, 300 Shire Way, Lexington, MA 02421, USA.
  • Cao H; Shire, 300 Shire Way, Lexington, MA 02421, USA.
  • Brown E; Shire, 300 Shire Way, Lexington, MA 02421, USA.
  • Hayes MA; Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA.
  • Beagan J; Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA.
  • McLean JR; Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA.
  • Izen SC; Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA.
  • Perez-Torres E; Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA.
  • Hallett PJ; Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA. Electronic address: phallett@mclean.harvard.edu.
  • Isacson O; Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA. Electronic address: isacson@hms.harvard.edu.
Neurobiol Dis ; 82: 495-503, 2015 Oct.
Article em En | MEDLINE | ID: mdl-26392287
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mesencéfalo / Terapia Genética / Doenças Neurodegenerativas / Alfa-Sinucleína / Neurônios Dopaminérgicos / Glucosilceramidase Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mesencéfalo / Terapia Genética / Doenças Neurodegenerativas / Alfa-Sinucleína / Neurônios Dopaminérgicos / Glucosilceramidase Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article