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Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia.
Iacovelli, Stefano; Ricciardi, Maria Rosaria; Allegretti, Matteo; Mirabilii, Simone; Licchetta, Roberto; Bergamo, Paola; Rinaldo, Cinzia; Zeuner, Ann; Foà, Robin; Milella, Michele; McCubrey, James A; Martelli, Alberto M; Tafuri, Agostino.
Afiliação
  • Iacovelli S; Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Italy.
  • Ricciardi MR; Hematology, "Sant'Andrea" Hospital - Sapienza University of Rome, Department of Clinical and Molecular Medicine, Rome, Italy.
  • Allegretti M; Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Italy.
  • Mirabilii S; Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Italy.
  • Licchetta R; Hematology, "Sant'Andrea" Hospital - Sapienza University of Rome, Department of Clinical and Molecular Medicine, Rome, Italy.
  • Bergamo P; Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Italy.
  • Rinaldo C; Institute of Molecular Biology and Pathology, National Research Council, Rome, Italy.
  • Zeuner A; Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
  • Foà R; Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Italy.
  • Milella M; Department of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy.
  • McCubrey JA; Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, USA.
  • Martelli AM; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • Tafuri A; Hematology, "Sant'Andrea" Hospital - Sapienza University of Rome, Department of Clinical and Molecular Medicine, Rome, Italy.
Oncotarget ; 6(31): 32089-103, 2015 Oct 13.
Article em En | MEDLINE | ID: mdl-26392332

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Proteínas Proto-Oncogênicas / Apoptose / Resistencia a Medicamentos Antineoplásicos / Proteínas Proto-Oncogênicas c-bcl-2 / Sinergismo Farmacológico / Leucemia-Linfoma Linfoblástico de Células Precursoras / Serina-Treonina Quinases TOR Tipo de estudo: Prognostic_studies Limite: Adult / Child / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Proteínas Proto-Oncogênicas / Apoptose / Resistencia a Medicamentos Antineoplásicos / Proteínas Proto-Oncogênicas c-bcl-2 / Sinergismo Farmacológico / Leucemia-Linfoma Linfoblástico de Células Precursoras / Serina-Treonina Quinases TOR Tipo de estudo: Prognostic_studies Limite: Adult / Child / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article