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Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs.
Behrens, Christopher R; Ha, Edward H; Chinn, Lawrence L; Bowers, Simeon; Probst, Gary; Fitch-Bruhns, Maureen; Monteon, Jorge; Valdiosera, Amanda; Bermudez, Abel; Liao-Chan, Sindy; Wong, Tiffany; Melnick, Jonathan; Theunissen, Jan-Willem; Flory, Mark R; Houser, Derrick; Venstrom, Kristy; Levashova, Zoia; Sauer, Paul; Migone, Thi-Sau; van der Horst, Edward H; Halcomb, Randall L; Jackson, David Y.
Afiliação
  • Behrens CR; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Ha EH; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Chinn LL; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Bowers S; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Probst G; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Fitch-Bruhns M; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Monteon J; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Valdiosera A; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Bermudez A; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Liao-Chan S; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Wong T; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Melnick J; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Theunissen JW; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Flory MR; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Houser D; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Venstrom K; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Levashova Z; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Sauer P; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Migone TS; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • van der Horst EH; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Halcomb RL; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
  • Jackson DY; Igenica Biotherapeutics , 863A Mitten Road, Suite 100B, Burlingame, California 94010, United States.
Mol Pharm ; 12(11): 3986-98, 2015 Nov 02.
Article em En | MEDLINE | ID: mdl-26393951
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoconjugados / Cisteína / Trastuzumab / Neoplasias Pulmonares / Anticorpos Monoclonais / Antineoplásicos Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoconjugados / Cisteína / Trastuzumab / Neoplasias Pulmonares / Anticorpos Monoclonais / Antineoplásicos Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article