Granulomatous Lobular Mastitis.
Isr Med Assoc J
; 17(8): 476-80, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26394488
ABSTRACT
BACKGROUND:
Granulomatous lobular mastitis (GLM) is a rare disorder that can clinically mimic breast carcinoma. The recommendation for diagnosis and treatment of GLM has not yet been established.OBJECTIVES:
To assess a series of GLM patients, including their clinical presentation, diagnosis, treatment and outcome.METHODS:
We retrospectively analyzed the clinical data and treatment of 17 female patients with biopsy-proven GLM. Breast tissue was obtained by a core needle biopsy (15 patients) or open biopsy (2 patients). Images were reviewed by an experienced radiologist.RESULTS:
The mean age of the patients at diagnosis was 44.6 ± 12.6 years. Five patients (29%) presented with bilateral disease, and seven (41%) presented with a mass, suggesting the initial diagnosis of breast carcinoma. Treatment comprised observation alone (23%), antibiotics (58.8%) and/or corticosteroids (with or without methotrexate) (35%). At the end of the study 70.6% of the patients demonstrated complete remission. None of the patients developed any systemic (granulomatous) disease or breast carcinoma during the follow-up period (4.7 ± 3.8 years).CONCLUSIONS:
Core needle biopsy is mandatory for the diagnosis of GLM and the exclusion of breast carcinoma. The recommended treatment modalities are observation alone or corticosteroids; surgery should be avoided. GLM is a benign disease with a high rate of resolution and complete remission.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Mama
/
Neoplasias da Mama
/
Metotrexato
/
Mastite Granulomatosa
/
Glucocorticoides
/
Antibacterianos
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article