Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages.
Bioorg Med Chem Lett
; 25(22): 5389-92, 2015 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-26403929
ABSTRACT
The formation of foam cells in macrophages has been suggested to play an essential role in the progression of early atherosclerotic lesions in vivo and, thus, its suppression is considered to be one of the major approaches for the treatment of atherosclerosis. We isolated eight brominated-tyrosine derivatives, bastadins, from the EtOH extract of the marine sponge Ianthella vasta as inhibitors of the formation of foam cells induced by acetylated low-density lipoproteins in human monocyte-derived macrophages. Bastadin 6 was the strongest inhibitor of foam cell formation due to its suppression of acyl-coenzyme Acholesterol acyltransferase.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tirosina
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Ésteres do Colesterol
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Éteres Difenil Halogenados
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Células Espumosas
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article