Amyotrophic lateral sclerosis models derived from human embryonic stem cells with different superoxide dismutase 1 mutations exhibit differential drug responses.

Isobe, Takehisa; Tooi, Norie; Nakatsuji, Norio; Aiba, Kazuhiro

Isobe, Takehisa; Tooi, Norie; Nakatsuji, Norio; Aiba, Kazuhiro.

Afiliação

Isobe T; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8501, Japan; Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Tooi N; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8501, Japan.
Nakatsuji N; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8501, Japan; Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Aiba K; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8501, Japan. Electronic address: kaiba@icems.kyoto-u.ac.jp.

Stem Cell Res ; 15(3): 459-468, 2015 Nov.

Article em En | MEDLINE | ID: mdl-26413785

Assuntos

Esclerose Lateral Amiotrófica/genética; Neurônios Motores/efeitos dos fármacos; Superóxido Dismutase/genética; Esclerose Lateral Amiotrófica/metabolismo; Células-Tronco Embrionárias Humanas; Humanos; Mutação; Superóxido Dismutase/metabolismo; Superóxido Dismutase-1

Palavras-chave

Amyotrophic lateral sclerosis; Drug response; Human embryonic stem cell; Motor neuron; SOD1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Superóxido Dismutase / Esclerose Lateral Amiotrófica / Neurônios Motores Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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