Surfactant Effects on Particle Generation in Antibody Formulations in Pre-filled Syringes.

Gerhardt, Alana; Mcumber, Aaron C; Nguyen, Bao H; Lewus, Rachael; Schwartz, Daniel K; Carpenter, John F; Randolph, Theodore W

Gerhardt, Alana; Mcumber, Aaron C; Nguyen, Bao H; Lewus, Rachael; Schwartz, Daniel K; Carpenter, John F; Randolph, Theodore W.

Afiliação

Gerhardt A; Department of Chemical and Biological Engineering, University of Colorado-Boulder, Boulder, Colorado.
Mcumber AC; Department of Chemical and Biological Engineering, University of Colorado-Boulder, Boulder, Colorado.
Nguyen BH; Department of Chemical and Biological Engineering, University of Colorado-Boulder, Boulder, Colorado.
Lewus R; Formulation Sciences Department, MedImmune, Gaithersburg, Maryland.
Schwartz DK; Department of Chemical and Biological Engineering, University of Colorado-Boulder, Boulder, Colorado.
Carpenter JF; Department of Pharmaceutical Sciences, University of Colorado-Denver, Aurora, Colorado.
Randolph TW; Department of Chemical and Biological Engineering, University of Colorado-Boulder, Boulder, Colorado. Electronic address: theodore.randolph@colorado.edu.

J Pharm Sci ; 104(12): 4056-4064, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26413998

Assuntos

Anticorpos Monoclonais/química; Anticorpos Monoclonais/imunologia; Formação de Anticorpos/imunologia; Tensoativos/química; Química Farmacêutica/métodos; Géis/química; Polissorbatos/química; Óleos de Silicone/química; Seringas; Água/química

Palavras-chave

PFS; TIRFM; adsorption; interfacial diffusion; microparticles; monoclonal antibody; protein aggregation; protein gelation; silicone oil; surfactant

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tensoativos / Anticorpos Monoclonais / Formação de Anticorpos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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