Synthesis of bridged diketopiperazines by using the persistent radical effect and a formal synthesis of bicyclomycin.
Angew Chem Int Ed Engl
; 54(41): 12153-7, 2015 Oct 05.
Article
em En
| MEDLINE
| ID: mdl-26418182
ABSTRACT
A conceptually new and unified approach to diverse bridged diketopiperazines (DKPs) with widely variable ring sizes was developed by taking advantage of the persistent radical effect. This method enables synthesis of the core structures of bridged DKP alkaloids and was applied to a formal synthesis of the antibiotic bicyclomycin.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dicetopiperazinas
/
Antibacterianos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article