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Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors.
Goswami, Rajeev; Wohlfahrt, Gerd; Törmäkangas, Olli; Moilanen, Anu; Lakshminarasimhan, Anirudha; Nagaraj, Jwala; Arumugam, Karthikeyan N; Mukherjee, Subhendu; Chacko, Anita R; Krishnamurthy, Narasimha R; Jaleel, Mahaboobi; Palakurthy, Rajendra K; Samiulla, Dodheri S; Ramachandra, Murali.
Afiliação
  • Goswami R; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India.
  • Wohlfahrt G; Orion Corporation, Orionintie 1, FIN-02101 Espoo, Finland.
  • Törmäkangas O; Orion Corporation, Tengströminkatu 8, FIN-20101 Turku, Finland.
  • Moilanen A; Orion Corporation, Tengströminkatu 8, FIN-20101 Turku, Finland.
  • Lakshminarasimhan A; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India.
  • Nagaraj J; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India.
  • Arumugam KN; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India.
  • Mukherjee S; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India.
  • Chacko AR; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India.
  • Krishnamurthy NR; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India.
  • Jaleel M; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India.
  • Palakurthy RK; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India.
  • Samiulla DS; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India.
  • Ramachandra M; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore 560 100, India. Electronic address: murali_r@aurigene.com.
Bioorg Med Chem Lett ; 25(22): 5309-14, 2015 Nov 15.
Article em En | MEDLINE | ID: mdl-26421993
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Serina Endopeptidases / Inibidores de Serina Proteinase / Cicloexanos / Indóis / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Serina Endopeptidases / Inibidores de Serina Proteinase / Cicloexanos / Indóis / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article