Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages.
Bioorg Med Chem Lett
; 25(22): 5295-8, 2015 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-26428873
ABSTRACT
In 2014, we isolated kurahyne, an acetylene-containing lipopeptide, from a marine cyanobacterial assemblage of Lyngbya sp. Kurahyne exhibited growth-inhibitory activity against human cancer cells, and induced apoptosis in HeLa cells. However, its mode of action is not yet clear. To elucidate its mode of action, we carried out several cell-based assays, and identified the intracellular target molecule of kurahyne as sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA). In addition, we found that kurahyne inhibited the differentiation of macrophages into osteoclasts.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alcinos
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ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático
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Oscillatoria
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Lipopeptídeos
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Antineoplásicos
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article