Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells.

Okamura, Tatsunori; Antoun, Gamil; Keir, Stephen T; Friedman, Henry; Bigner, Darell D; Ali-Osman, Francis

Okamura, Tatsunori; Antoun, Gamil; Keir, Stephen T; Friedman, Henry; Bigner, Darell D; Ali-Osman, Francis.

Afiliação

Okamura T; From the Departments of Neurosurgery and.
Antoun G; From the Departments of Neurosurgery and.
Keir ST; From the Departments of Neurosurgery and the Preston Robert Tisch Brain Tumor Center.
Friedman H; From the Departments of Neurosurgery and the Preston Robert Tisch Brain Tumor Center, Duke Cancer Institute and Duke University School of Medicine, Durham, North Carolina 27710.
Bigner DD; From the Departments of Neurosurgery and the Preston Robert Tisch Brain Tumor Center, Duke Cancer Institute and Duke University School of Medicine, Durham, North Carolina 27710 Pathology and.
Ali-Osman F; From the Departments of Neurosurgery and the Preston Robert Tisch Brain Tumor Center, Duke Cancer Institute and Duke University School of Medicine, Durham, North Carolina 27710 Pathology and francis.aliosman@duke.edu.

J Biol Chem ; 290(52): 30866-78, 2015 Dec 25.

Article em En | MEDLINE | ID: mdl-26429914

Assuntos

Apoptose; Neoplasias Encefálicas/enzimologia; Receptores ErbB/metabolismo; Glutationa S-Transferase pi/metabolismo; Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo; Transdução de Sinais; Motivos de Aminoácidos; Animais; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/metabolismo; Neoplasias Encefálicas/fisiopatologia; Linhagem Celular Tumoral; Receptores ErbB/genética; Glutationa S-Transferase pi/química; Glutationa S-Transferase pi/genética; Humanos; Proteínas Quinases JNK Ativadas por Mitógeno/genética; Camundongos Endogâmicos BALB C; Camundongos Nus; Fosforilação; Ligação Proteica

Palavras-chave

apoptosis; brain tumor; c-Jun N-terminal kinase (JNK); epidermal growth factor receptor (EGFR); phosphorylation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Transdução de Sinais / Apoptose / Proteínas Quinases JNK Ativadas por Mitógeno / Glutationa S-Transferase pi / Receptores ErbB Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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