Combination therapy for multidrug-resistant cytomegalovirus disease.
Transpl Infect Dis
; 17(5): 751-5, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26432076
ABSTRACT
Multidrug-resistant (MDR) cytomegalovirus (CMV) emerged after transient responses to ganciclovir, foscarnet, and cidofovir in a CMV-seropositive recipient who underwent allogeneic hematopoietic stem cell transplantation from a CMV-seronegative donor. Experimental treatments using leflunomide and artesunate failed. Re-transplantation from a CMV-seropositive donor supported by adoptive transfer of pp65-specific T cells and maribavir was followed by lasting suppression. This case illustrates that successful MDR CMV therapy may require individualized multidisciplinary approaches.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Hospedeiro Imunocomprometido
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Infecções por Citomegalovirus
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Transplante de Células-Tronco Hematopoéticas
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Farmacorresistência Viral Múltipla
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article