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Combination therapy for multidrug-resistant cytomegalovirus disease.
Stuehler, C; Stüssi, G; Halter, J; Nowakowska, J; Schibli, A; Battegay, M; Dirks, J; Passweg, J; Heim, D; Rovo, A; Kalberer, C; Bucher, C; Weisser, M; Dumoulin, A; Hirsch, H H; Khanna, N.
Afiliação
  • Stuehler C; Infection Biology Laboratory, Department of Biomedicine, University and University Hospital of Basel, Basel, Switzerland.
  • Stüssi G; Division of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Halter J; Division of Hematology, Department of Biomedicine and Clinical Research, University Hospital of Basel, Basel, Switzerland.
  • Nowakowska J; Infection Biology Laboratory, Department of Biomedicine, University and University Hospital of Basel, Basel, Switzerland.
  • Schibli A; Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland.
  • Battegay M; Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland.
  • Dirks J; Division of Hematology, Department of Biomedicine and Clinical Research, University Hospital of Basel, Basel, Switzerland.
  • Passweg J; Division of Hematology, Department of Biomedicine and Clinical Research, University Hospital of Basel, Basel, Switzerland.
  • Heim D; Division of Hematology, Department of Biomedicine and Clinical Research, University Hospital of Basel, Basel, Switzerland.
  • Rovo A; Division of Hematology, Department of Biomedicine and Clinical Research, University Hospital of Basel, Basel, Switzerland.
  • Kalberer C; Division of Hematology, Department of Biomedicine and Clinical Research, University Hospital of Basel, Basel, Switzerland.
  • Bucher C; Division of Hematology, Department of Biomedicine and Clinical Research, University Hospital of Basel, Basel, Switzerland.
  • Weisser M; Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland.
  • Dumoulin A; Transplantation & Clinical Virology, Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Hirsch HH; Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland.
  • Khanna N; Transplantation & Clinical Virology, Department of Biomedicine, University of Basel, Basel, Switzerland.
Transpl Infect Dis ; 17(5): 751-5, 2015 Oct.
Article em En | MEDLINE | ID: mdl-26432076
ABSTRACT
Multidrug-resistant (MDR) cytomegalovirus (CMV) emerged after transient responses to ganciclovir, foscarnet, and cidofovir in a CMV-seropositive recipient who underwent allogeneic hematopoietic stem cell transplantation from a CMV-seronegative donor. Experimental treatments using leflunomide and artesunate failed. Re-transplantation from a CMV-seropositive donor supported by adoptive transfer of pp65-specific T cells and maribavir was followed by lasting suppression. This case illustrates that successful MDR CMV therapy may require individualized multidisciplinary approaches.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hospedeiro Imunocomprometido / Infecções por Citomegalovirus / Transplante de Células-Tronco Hematopoéticas / Farmacorresistência Viral Múltipla Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hospedeiro Imunocomprometido / Infecções por Citomegalovirus / Transplante de Células-Tronco Hematopoéticas / Farmacorresistência Viral Múltipla Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article