2Dâ
NMR Trace Analysis by Continuous Hyperpolarization at High Magnetic Field.
Angew Chem Int Ed Engl
; 54(48): 14527-30, 2015 Nov 23.
Article
em En
| MEDLINE
| ID: mdl-26437608
ABSTRACT
Nuclear magnetic resonance is often the technique of choice in chemical analysis because of its sensitivity to molecular structure, quantitative character, and straightforward sample preparation. However, determination of trace analytes in complex mixtures is generally limited by low sensitivity and extensive signal overlap. Here, we present an approach for continuous hyperpolarization at high magnetic field that is based on signal amplification by reversible exchange (SABRE) and can be straightforwardly incorporated in multidimensional NMR experiments. This method was implemented in a 2Dâ
correlation experiment that allows detection and quantification of analytes at nanomolar concentration in complex solutions.
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MEDLINE
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En
Ano de publicação:
2015
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Article