Clinical development of RTS,S/AS malaria vaccine: a systematic review of clinical Phase I-III trials.
Future Microbiol
; 10(10): 1553-78, 2015.
Article
em En
| MEDLINE
| ID: mdl-26437872
ABSTRACT
The first clinical Phase III trial evaluating a malaria vaccine was completed in December 2013 at 11 sites from seven sub-Saharan African countries. This systematic review assesses data of Phase I-III trials including malaria-naive adults and adults, children and infants from malaria endemic settings in sub-Saharan Africa. The main endpoint of this systematic review was an analysis of the consistency of efficacy and immunogenicity data from respective Phase I-III trials. In addition, safety data from a pooled analysis of RTS/AS Phase II trials and RTS,S/AS01 Phase III trial were reviewed. The RTS,S/AS01 malaria vaccine may become available on the market in the coming year. If so, further strategies should address challenges on how to optimize vaccine efficacy and implementation of RTS,S/AS01 vaccine within the framework of established malaria control measures.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Malária Falciparum
/
Vacinas Antimaláricas
Tipo de estudo:
Systematic_reviews
Limite:
Adult
/
Child
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Child, preschool
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Humans
/
Infant
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article