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Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection.
Siggs, Owen M; Popkin, Daniel L; Krebs, Philippe; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Zeng, Ming; Lin, Pei; Xia, Yu; Oldstone, Michael B A; Cornall, Richard J; Beutler, Bruce.
Afiliação
  • Siggs OM; Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037; Medical Research Council Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom; Bruce.Beutler@UTSouthwestern.edu owen.siggs@gmail.com.
  • Popkin DL; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037;
  • Krebs P; Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037;
  • Li X; Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Tang M; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Zhan X; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Zeng M; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Lin P; Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037;
  • Xia Y; Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037;
  • Oldstone MB; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037;
  • Cornall RJ; Medical Research Council Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom;
  • Beutler B; Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390 Bruce.Beutler@UTSouthwestern.edu owen.siggs@gmail.com.
Proc Natl Acad Sci U S A ; 112(42): E5706-14, 2015 Oct 20.
Article em En | MEDLINE | ID: mdl-26438836
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Viroses / Receptores de Peptídeos / Predisposição Genética para Doença / Retículo Endoplasmático / Linfopenia / Mutação Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Viroses / Receptores de Peptídeos / Predisposição Genética para Doença / Retículo Endoplasmático / Linfopenia / Mutação Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article