Carotid Intima-Media Thickness in Patients With a History of Kawasaki Disease.
Circ J
; 79(12): 2682-7, 2015.
Article
em En
| MEDLINE
| ID: mdl-26439324
ABSTRACT
BACKGROUND:
Kawasaki disease (KD) is an acute pediatric vasculitis with coronary artery aneurysms (CAA) as its main complication. Concerns have been raised regarding the possibility of a predisposition of KD to premature cardiovascular disease (CVD) risk later in life. Our aim was to assess carotid intima-media thickness (cIMT), as a surrogate marker of CVD risk, in patients with a history of KD compared with unaffected controls. METHODSâANDâRESULTS:
B-mode ultrasound cIMT measurements were performed in 168 patients with a history of KD, and 82 controls; 7 patients were excluded because of incomplete cIMT assessments. Mean cIMT (±SD) was increased in patients with KD compared with controls (0.378±0.030 mm vs. 0.360±0.027 mm, respectively; P adjusted <0.0001). If the cIMTs of CAA-negative patients and controls were plotted against age, increased cIMT was only apparent at young age. In patients with CAA, increased cIMT was observed over the entire age range.CONCLUSIONS:
Our findings show that arterial wall thickening is more apparent in patients with a history of KD as compared with controls. In CAA-negative patients, cIMT is indistinguishable from controls at older age, whereas an increased cIMT is observed at any age in patients with CAA, suggesting a more general and severe effect of KD on the arterial wall.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aneurisma Coronário
/
Espessura Intima-Media Carotídea
/
Síndrome de Linfonodos Mucocutâneos
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article