Efficient Gene Editing in Primary Human T Cells.
Trends Immunol
; 36(11): 667-669, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26440702
ABSTRACT
Recent advances in T-cell therapy for cancer, viral infections, and autoimmune diseases highlight the broad therapeutic potential of T-cell engineering. However, site-specific genetic manipulation in primary human T cells remains challenging. Two recent studies describe efficient genome editing in T cells using CRISPR and TALEN approaches.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Engenharia Genética
/
Endonucleases
/
Sistemas CRISPR-Cas
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article