[Diagnostic Significance of BAT in Anaphylaxis to Non-ionic Contrast Media].
Fa Yi Xue Za Zhi
; 31(3): 188-90, 2015 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-26442369
ABSTRACT
OBJECTIVE:
To investigate the diagnostic significance of basophil activation test (BAT) in anaphylaxis to non-ionic contrast media through testing the content of CD63, mast cell-carboxypeptidase A3 (MC-CPA3), and terminal complement complex SC5b-9 of the individuals by testing their levels in the normal immune group and the anaphylaxis groups to ß-lactam drugs and non -ionic contrast media.METHODS:
The CD63 expression of basophilic granulocyte in blood was detected by flow cytometry. The levels of MC-CPA3 in blood serum and SC5b-9 in blood plasma were detected by ELISA.RESULTS:
The CD63 expression of basophilic granulocyte in blood, the levels of MC-CPA3 and SC5b-9 of anaphylaxis to non-ionic contrast media and ß-lactam drugs were significantly higher than that in normal immune group (P < 0.05).CONCLUSION:
There is activation of basophilic granulocytes, mast cells and complement system in anaphylaxis to non-ionic contrast media. BAT can be used to diagnose the anaphylaxis to non-ionic contrast media.
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Base de dados:
MEDLINE
Assunto principal:
Basófilos
/
Meios de Contraste
/
Anafilaxia
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2015
Tipo de documento:
Article