Giving Time Purpose: The Synechococcus elongatus Clock in a Broader Network Context.
Annu Rev Genet
; 49: 485-505, 2015.
Article
em En
| MEDLINE
| ID: mdl-26442846
ABSTRACT
Early research on the cyanobacterial clock focused on characterizing the genes needed to keep, entrain, and convey time within the cell. As the scope of assays used in molecular genetics has expanded to capture systems-level properties (e.g., RNA-seq, ChIP-seq, metabolomics, high-throughput screening of genetic variants), so has our understanding of how the clock fits within and influences a broader cellular context. Here we review the work that has established a global perspective of the clock, with a focus on (a) an emerging network-centric view of clock architecture, (b) mechanistic insights into how temporal and environmental cues are transmitted and integrated within this network,
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Base de dados:
MEDLINE
Assunto principal:
Ritmo Circadiano
/
Synechococcus
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article