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Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers.
Subramanian, Romesh R; Wysk, Mark A; Ogilvie, Kathleen M; Bhat, Abhijit; Kuang, Bing; Rockel, Thomas D; Weber, Markus; Uhlmann, Eugen; Krieg, Arthur M.
Afiliação
  • Subramanian RR; RaNA Therapeutics LLC, 790 Memorial Dr., Suite 203, Cambridge, MA 02139, USA.
  • Wysk MA; RaNA Therapeutics LLC, 790 Memorial Dr., Suite 203, Cambridge, MA 02139, USA.
  • Ogilvie KM; Pfizer Worldwide Research and Development, 9381 Judicial Dr., Suite 200, San Diego, CA 92121, USA.
  • Bhat A; Pfizer Worldwide Research and Development, 9381 Judicial Dr., Suite 200, San Diego, CA 92121, USA.
  • Kuang B; Pfizer Worldwide Research and Development, 9381 Judicial Dr., Suite 200, San Diego, CA 92121, USA.
  • Rockel TD; Coley Pharmaceutical GmbH, Merowingerplatz 1a, 40225 Dusseldorf, Germany.
  • Weber M; Coley Pharmaceutical GmbH, Merowingerplatz 1a, 40225 Dusseldorf, Germany.
  • Uhlmann E; Coley Pharmaceutical GmbH, Merowingerplatz 1a, 40225 Dusseldorf, Germany.
  • Krieg AM; RaNA Therapeutics LLC, 790 Memorial Dr., Suite 203, Cambridge, MA 02139, USA cpgrocks@gmail.com.
Nucleic Acids Res ; 43(19): 9123-32, 2015 Oct 30.
Article em En | MEDLINE | ID: mdl-26446989
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligonucleotídeos Antissenso Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligonucleotídeos Antissenso Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article