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The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain.
Fluteau, Adeline; Ince, Paul G; Minett, Thais; Matthews, Fiona E; Brayne, Carol; Garwood, Claire J; Ratcliffe, Laura E; Morgan, Sarah; Heath, Paul R; Shaw, Pamela J; Wharton, Stephen B; Simpson, Julie E.
Afiliação
  • Fluteau A; Sheffield Institute for Translational Neuroscience, University of Sheffield, United Kingdom; MRC Human Genetics Unit, University of Edinburgh, United Kingdom.
  • Ince PG; Sheffield Institute for Translational Neuroscience, University of Sheffield, United Kingdom.
  • Minett T; Institute of Public Health, University of Cambridge, United Kingdom; Department of Radiology, University of Cambridge, United Kingdom.
  • Matthews FE; MRC Biostatistics Unit, Cambridge, United Kingdom; Institute of Health and Society, University of Newcastle, United Kingdom; Faculty of Life Sciences, University of Manchester, United Kingdom.
  • Brayne C; Institute of Public Health, University of Cambridge, United Kingdom.
  • Garwood CJ; Sheffield Institute for Translational Neuroscience, University of Sheffield, United Kingdom.
  • Ratcliffe LE; Sheffield Institute for Translational Neuroscience, University of Sheffield, United Kingdom.
  • Morgan S; Sheffield Institute for Translational Neuroscience, University of Sheffield, United Kingdom.
  • Heath PR; Sheffield Institute for Translational Neuroscience, University of Sheffield, United Kingdom.
  • Shaw PJ; Sheffield Institute for Translational Neuroscience, University of Sheffield, United Kingdom.
  • Wharton SB; Sheffield Institute for Translational Neuroscience, University of Sheffield, United Kingdom. Electronic address: s.wharton@sheffield.ac.uk.
  • Simpson JE; Sheffield Institute for Translational Neuroscience, University of Sheffield, United Kingdom.
Neurosci Lett ; 609: 11-7, 2015 Nov 16.
Article em En | MEDLINE | ID: mdl-26455863
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Encéfalo / Núcleo Celular / Astrócitos / Demência / Fatores de Transcrição Forkhead / Glutamato-Amônia Ligase Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Encéfalo / Núcleo Celular / Astrócitos / Demência / Fatores de Transcrição Forkhead / Glutamato-Amônia Ligase Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article