Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation.
Sci Rep
; 5: 15066, 2015 Oct 14.
Article
em En
| MEDLINE
| ID: mdl-26463758
ABSTRACT
Polyreactive antibodies are a major component of the natural antibody repertoire and bind to a variety of structurally unrelated molecules. These antibodies are thought to provide a first line of defense against bacterial infections and play a major role in the clearance of apoptotic cells. What triggers the secretion of these antibodies has remained an enigma. Using a surrogate assay for measuring polyreactive antibodies, we found that about 50% of serum IgM is polyreactive and that stimulation of TLR4(+/+), but not TLR4(-/-), mice resulted in a 40 fold increase in polyreactive antibodies. Stimulation of TLRs 3, 7, 9 also increased the secretion of polyreactive antibodies. Infection with a virus or tissue damage induced by a toxin similarly led to an increase in polyreactive antibodies in MyD88(+/+), but not MyD88(-/-) mice. We conclude that stimulation of TLRs is a key link in the mechanism of polyreactive antibody secretion into the circulation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Imunização
/
Receptores Toll-Like
/
Imunidade Inata
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article