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New Perspectives for the Rescue of Cognitive Disability in Down Syndrome.
Bartesaghi, Renata; Haydar, Tarik F; Delabar, Jean Maurice; Dierssen, Mara; Martínez-Cué, Carmen; Bianchi, Diana W.
Afiliação
  • Bartesaghi R; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna 40126, Italy.
  • Haydar TF; Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118.
  • Delabar JM; Unit of Functional and Adaptative Biology, University Paris Diderot, Paris 75013, France.
  • Dierssen M; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain.
  • Martínez-Cué C; Department of Physiology and Pharmacology, University of Cantabria, Santander 39011, Spain, and.
  • Bianchi DW; Mother Infant Research Institute, Floating Hospital for Children and Department of Pediatrics, Tufts University School of Medicine, Boston, Massachusetts 02111 dbianchi@tuftsmedicalcenter.org.
J Neurosci ; 35(41): 13843-52, 2015 Oct 14.
Article em En | MEDLINE | ID: mdl-26468184
Down syndrome (DS) is a relatively common genetic condition caused by the triplication of human chromosome 21. No therapies currently exist for the rescue of neurocognitive impairment in DS. This review presents exciting findings showing that it is possible to restore brain development and cognitive performance in mouse models of DS with therapies that can also apply to humans. This knowledge provides a potential breakthrough for the prevention of intellectual disability in DS.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Down / Transtornos Cognitivos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Down / Transtornos Cognitivos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article