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Targeting EGFR/HER2 tyrosine kinases with a new potent series of 6-substituted 4-anilinoquinazoline hybrids: Design, synthesis, kinase assay, cell-based assay, and molecular docking.
Elkamhawy, Ahmed; Farag, Ahmed Karam; Viswanath, Ambily Nath Indu; Bedair, Tarek M; Leem, Dong Gyu; Lee, Kyung-Tae; Pae, Ae Nim; Roh, Eun Joo.
Afiliação
  • Elkamhawy A; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea; Department of Biological Chemistry, Korea University of Science and Technology (UST), Daejeon 305-350, South Korea; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Ma
  • Farag AK; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea; Department of Biological Chemistry, Korea University of Science and Technology (UST), Daejeon 305-350, South Korea.
  • Viswanath AN; Department of Biological Chemistry, Korea University of Science and Technology (UST), Daejeon 305-350, South Korea; Center for Neuro-Medicine, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea.
  • Bedair TM; Department of Biomedical Engineering, Korea University of Science and Technology (UST), Daejeon 305-350, South Korea; Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea.
  • Leem DG; Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, South Korea.
  • Lee KT; Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, South Korea.
  • Pae AN; Department of Biological Chemistry, Korea University of Science and Technology (UST), Daejeon 305-350, South Korea; Center for Neuro-Medicine, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea.
  • Roh EJ; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea; Department of Biological Chemistry, Korea University of Science and Technology (UST), Daejeon 305-350, South Korea. Electronic address: r8636@kist.re.kr.
Bioorg Med Chem Lett ; 25(22): 5147-54, 2015 Nov 15.
Article em En | MEDLINE | ID: mdl-26475520
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Receptor ErbB-2 / Inibidores de Proteínas Quinases / Receptores ErbB / Compostos de Anilina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Receptor ErbB-2 / Inibidores de Proteínas Quinases / Receptores ErbB / Compostos de Anilina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article