MicroRNA as biomarkers of mitochondrial toxicity.

Baumgart, Bethany R; Gray, Katherine L; Woicke, Jochen; Bunch, Roderick T; Sanderson, Thomas P; Van Vleet, Terry R

Baumgart, Bethany R; Gray, Katherine L; Woicke, Jochen; Bunch, Roderick T; Sanderson, Thomas P; Van Vleet, Terry R.

Afiliação

Baumgart BR; Department of Toxicology, Drug Safety Evaluation, Bristol-Myers Squibb, 4401 Highway 62 East, Mount Vernon, IN 47620, USA. Electronic address: bethany.baumgart@bms.com.
Gray KL; Department of Toxicology, Drug Safety Evaluation, Bristol-Myers Squibb, 4401 Highway 62 East, Mount Vernon, IN 47620, USA.
Woicke J; Department of Pathology, Drug Safety Evaluation, Bristol-Myers Squibb, 4401 Highway 62 East, Mount Vernon, IN 47620, USA.
Bunch RT; Department of Toxicology, Drug Safety Evaluation, Bristol-Myers Squibb, 4401 Highway 62 East, Mount Vernon, IN 47620, USA.
Sanderson TP; Department of Toxicology, Drug Safety Evaluation, Bristol-Myers Squibb, 4401 Highway 62 East, Mount Vernon, IN 47620, USA.
Van Vleet TR; Department of Investigative Toxicology and Pathology, Abbvie, 1 N. Waukegan Rd., North Chicago, IL 60064-6123, USA.

Toxicol Appl Pharmacol ; 312: 26-33, 2016 Dec 01.

Article em En | MEDLINE | ID: mdl-26476301

Assuntos

MicroRNAs/genética; Mitocôndrias/efeitos dos fármacos; Nitrocompostos/toxicidade; Propionatos/toxicidade; Rotenona/toxicidade; Animais; DNA Mitocondrial/metabolismo; Masculino; Mitocôndrias/metabolismo; Ratos; Ratos Sprague-Dawley

Palavras-chave

Drug safety; MicroRNA; Mitochondria; Toxicity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Propionatos / Rotenona / MicroRNAs / Mitocôndrias / Nitrocompostos Tipo de estudo: Screening_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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